Science Weekly Secrets of ageing: how long could I live?
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Aug 1, 2024 
Venki Ramakrishnan, a Nobel Prize-winning chemist and author of 'Why We Die', dives into the science of aging and longevity. He discusses fascinating advancements in extending life, like stem cell therapies and the controversial notion of young blood transfusions. The conversation highlights the extreme measures the wealthy take, including cryonics, while also questioning their scientific validity. Ramakrishnan emphasizes the importance of lifestyle choices alongside medical innovations in navigating the future of aging and health.
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Telomeres: Double-Edged Sword
- Telomeres protect chromosomes but shorten with each cell division causing aging and senescence.
- Lengthening telomeres may increase cancer risk, so caution is needed with this anti-aging approach.
Stem Cell Reprogramming Potential
- Cellular reprogramming can revert specialized cells to pluripotent stem cells like in early embryos.
- Reprogramming shows age-related symptom improvements but risks cancer development and delivery challenges remain.
Clearing Senescent Cells Potential
- Drugs targeting senescent cells to reduce inflammation show promise in mice.
- Challenges remain to ensure specificity and safety in humans for long-term use.