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The Curbsiders Internal Medicine Podcast
#247 SPEP It Up: MGUS, Myeloma, and Immunology, Oh My!
Dec 21, 2020
Dr. Jorge Castillo from Harvard and Dana Farber joins the hosts to discuss topics such as immunology basics, limitations of the SPEP, when to suspect MGUS and myeloma, and how to talk to patients about these conditions. They also touch on Waldenstrom's and amyloidosis, providing valuable clinical insights and diagnostic frameworks. Tune in to learn more about these fascinating topics in internal medicine.
01:05:01
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Quick takeaways
- Plasma cell dyscrasias, such as myeloma, Waldenstrom's macroglobulinemia, and amyloidosis, are characterized by abnormal production of proteins known as paraproteins.
- Diagnosis of plasma cell dyscrasias involves various tests, including serum protein electrophoresis (S-PEP), immunofixation, and urine protein electrophoresis (U-PEP).
Deep dives
Different types of plasma cell dyscrasias
Plasma cell dyscrasias, such as myeloma, Waldenstrom's macroglobulinemia, and amyloidosis, are characterized by abnormal production of proteins known as paraproteins. Myeloma is the most common type and is associated with symptoms like hypercalcemia, renal dysfunction, anemia, and bone lesions. Waldenstrom's macroglobulinemia typically presents with anemia, hyperviscosity-related symptoms, and neuropathy, while amyloidosis primarily affects the kidneys, heart, and nerves.
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