AFP: American Family Physician Podcast Episode 221 -- January 2025 -- Part 1 AFP: American Family Physician
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Jan 15, 2025 Dive into a discussion about jaundice in adults, unraveling its causes and the importance of accurate diagnosis. Explore the intriguing potential of gepirone for treating major depressive disorder and its limitations. Learn about the short-term relief provided by steroid injections for hip osteoarthritis, along with insights on the effectiveness of various arthritis treatments. The episode also covers managing dysuria and highlights how ACE inhibitors and ARBs can impact diabetic kidney disease outcomes.
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Jaundice Explained
- Jaundice, a sign of hyperbilirubinemia, becomes noticeable when bilirubin exceeds 3 mg/dL.
- It signals a problem in bilirubin processing, affecting stool and urine color.
Hyperbilirubinemia Evaluation
- Evaluate unconjugated hyperbilirubinemia for overproduction of bilirubin or issues in conjugation or liver uptake.
- Conjugated hyperbilirubinemia arises from the body's inability to eliminate processed bilirubin.
Gepirone's Mechanism
- Gepirone, for major depressive disorder, primarily acts as a selective serotonin agonist at 5-HT1A receptors.
- It's similar to buspirone.