In this episode of AI Basics, Jason sits down with CapitalG partner Jill Chase to break down how AI is reshaping the startup ecosystem — from founders to investors to incumbents. They cover how CapitalG (Alphabet’s independent growth fund) thinks about the AI stack, why speed alone isn’t enough for startups today, and how to build durable advantages in a world where anyone can copy your product. Jill shares insights from portfolio companies like Motif (next-gen CAD for architecture) and Abridge (AI-powered doctor’s scribe), plus how startups can use AI “in the business” (product) and “on the business” (ops, GTM, etc). They also explore the transition from copilots to agents — and what that means for the next wave of software. If you’re building or investing in AI, this is a must-watch.

Timestamps:

(0:00) Jason kicks off the show

(1:10) CapitalG's investment strategy in AI

(3:04) Understanding value in AI investments

(5:16) Durability in AI startups and market challenges

(10:18) Practical applications of AI in business

(17:52) Case studies of successful AI startups

(21:35) Building massive businesses with small teams

(23:55) Evolution from AI copilots to autonomous agents

Uncover more valuable insights from AI leaders in Google Cloud's 'Future of AI: Perspectives for Startups' report. Discover what 23 AI industry leaders think about the future of AI—and how it impacts your business. Read their perspectives here: https://goo.gle/futureofai

Check out all of the Startup Basics episodes here: https://thisweekinstartups.com/basics

Check out Google Cloud: https://cloud.google.com/

Check out CapitalG: https://www.capitalg.com/

Follow Jill:

LinkedIn: https://www.linkedin.com/in/jill-greenberg-chase-53747538/

X: https://x.com/jillchase124

Follow Jason:

X: https://twitter.com/Jason

LinkedIn: https://www.linkedin.com/in/jasoncalacanis

Follow TWiST:

Twitter: https://twitter.com/TWiStartups

YouTube: https://www.youtube.com/thisweekin

Instagram: https://www.instagram.com/thisweekinstartups

TikTok: https://www.tiktok.com/@thisweekinstartups

Substack: https://twistartups.substack.com

Searching For SaaS

Nate’s Got Big News!

Remember Everything You Learn from Podcasts