OncoPharm FOLFOX (MOSAIC Trial)
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Dec 13, 2018 This discussion dives into the FOLFOX chemotherapy regimen and its significant impact on treating stage II and III colon cancer. It examines the historical development of 5-FU and clinical trials proving FOLFOX's efficacy and safety. The conversation also highlights the innovative CAPEX regimen, a three-week schedule involving capecitabine, and compares it to traditional treatments. The ongoing evolution in chemotherapy practices aims to improve effectiveness while minimizing side effects, marking important advancements in oncology pharmacy.
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Importance of FOLFOX Regimen
- FOLFOX is a key chemotherapy regimen for colorectal cancer used widely in oncology pharmacy.\n- It is considered a bread and butter regimen essential for pharmacy students to learn.
5-FU and Leucovorin History
- 5-FU was discovered in the 1950s, later enhanced by adding leucovorin to improve efficacy.\n- This combination set the foundation for adjuvant chemotherapy in colon cancer before FOLFOX.
Establishment of 5-FU Leucovorin
- Adjuvant 5-FU leucovorin became standard of care after showing survival benefits over earlier regimens.\n- Different 5-FU leucovorin dosing regimens exist, but most showed no difference in survival outcomes.