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VJHemOnc Podcast

Updates with the use of CAR-T therapy in ALL: ongoing challenges, strategies to overcome resistance & future outlooks

Feb 22, 2024
Renowned experts discuss challenges & advancements in CAR-T therapy for Acute Lymphoblastic Leukemia. Topics include dual targeting of CD19 & CD22, management considerations for patients, outcomes in post-transplant relapse, and strategies for T cell ALL treatment.
12:59

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Quick takeaways

  • Dual targeting of CD-19 and CD-22 in CAR-T therapy for ALL to overcome resistance and prevent relapse.
  • Tailored therapies and novel treatments are crucial for managing B-ALL patients prior to CAR-T therapy.

Deep dives

Challenges with CAR-T Therapy in ALL and Dual Targeting Approach

CAR-T therapy in acute lymphoblastic leukemia faces challenges such as target escape by malignant cells, leading to relapse. To overcome this, dual targeting of CD-19 and CD-22 is explored. Trials with co-administration and sequential administration of two cars have shown promising results, with the potential to improve outcomes and prevent relapse.

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