Complex Systems with Patrick McKenzie (patio11)

The future of pandemic preparedness, with Joshua Morrison

Dec 19, 2024

Joshua Morrison, CEO of 1Day Sooner and advocate for scientific advances in infectious disease response, joins the conversation. He shares insights on the successes and failures of Operation Warp Speed in vaccine development. Morrison highlights the need for innovative clean air technologies to improve pandemic preparedness and discusses the importance of effective communication and trust in public health. The conversation also touches on leveraging past experiences to enhance regulatory frameworks for rapid response to future pandemics.

01:13:17

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Episode guests

Joshua Morrison

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Episode notes

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Quick takeaways

Operation Warp Speed exemplified an innovative approach to rapidly develop COVID-19 vaccines through substantial funding and regulatory support.

One Day Sooner highlighted the importance of challenge studies, gathering thousands of volunteers to significantly accelerate vaccine research and efficacy.

Improving indoor air quality through advanced technologies is crucial for preventing airborne diseases and enhancing overall public health preparedness.

Deep dives

The Birth of One Day Sooner

One Day Sooner emerged during the COVID pandemic to address the urgent need for vaccine development through challenge studies, where volunteers are deliberately infected in controlled settings. The organization gathered a remarkable 40,000 volunteers from 165 countries eager to participate in studies aimed at accelerating vaccine efficacy against COVID. Such challenge studies were crucial as they helped push the boundaries of scientific research and vaccine innovation, particularly at a time when traditional methods were evolving slowly. One Day Sooner also represents the interests of volunteers willing to take risks for the collective benefit of fighting infectious diseases, a need highlighted by the pandemic.

Intro

3min

Vaccine Development: Lessons from the Pandemic

15min

Rapid Vaccine Development and Regulatory Reflections

3min

Enhancing Pandemic Preparedness Through Experience

19min

Vaccine Hesitancy and Communication Failures

17min

Innovative Solutions for Pandemic Preparedness

15min

Advancements in Pandemic Preparedness and Future Prospects

2min

In this episode, Patrick McKenzie (patio11) is joined by Joshua Morrison, the CEO of advocacy non-profit 1Day Sooner. They discuss what worked and what didn't in Operation Warp Speed's unprecedented push to develop COVID-19 vaccines. The conversation then turns to the future of pandemic preparedness, particularly the promising (and underappreciated) clean air technology. Throughout, Joshua and Patrick illuminate how institutional design choices, political incentives, and technical constraints shape our ability to respond to public health challenges.

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Full transcript available here: www.complexsystemspodcast.com/warp-speed-joshua-morrison/

Sponsors: GiveWell | Check

Support proven charities that deliver measurable results and learn how to maximize your charitable impact with GiveWell. Go to givewell.org (and type in "Complex Systems" at checkout).

Check is the leading payroll infrastructure provider and pioneer of embedded payroll. Check makes it easy for any SaaS platform to build a payroll business, and already powers 60+ popular platforms. Head to checkhq.com/complex and tell them patio11 sent you.

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Links:

1Day Sooner: https://www.1daysooner.org/
Patrick’s Complex Systems interview with Ross Rheingans-Yoo: https://open.spotify.com/episode/4GiO0KYqxJNCIdltCyhN6m
Patrick's Complex Systems interview with Dave Kasten about building VaccinateCA https://open.spotify.com/episode/66SSmxK2Kpyef7WUxXxS6w?si=VsSJMkktQiSGxtn9bFoOWA
Takeda's licensing deal with Moderna: https://www.takeda.com/newsroom/newsreleases/2021/takeda-announces-approval-of-modernas-covid-19-vaccine-in-japan/
Bits about Money: https://www.bitsaboutmoney.com/

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Twitter:
@joshcmorrison
@patio11

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Timestamps:

(00:00) Intro
(00:56) The role of challenge studies in vaccine development
(09:24) Understanding vaccine platforms
(18:33) Sponsor: Givewell | Check
(19:46) Regulatory system insights and future improvements
(20:41) Lessons for our regulatory system
(29:55) First doses first debate
(37:35) The surprising nature of COVID-19
(39:30) Vaccine hesitancy and public communication
(42:08) Political influence on vaccine distribution
(58:28) Indoor air quality and disease prevention
(01:06:52) Future of public health initiatives
(01:12:27) Wrap

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