EB. 129: The Forgotten Source of Oxalates: Your Body’s OWN Production

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Mar 6, 2025

Discover how your body produces oxalates and why it matters! The discussion dives into the impacts of vitamin C, glycine, and hydroxyproline on oxalate creation. Learn about metabolic dysfunction's role and how certain nutrients can reduce oxalate production. They also tackle rare genetic disorders like primary hyperoxaluria and the relationship between oxidative stress and kidney stones. Tune in to unravel the complex connections between your diet, metabolism, and health!

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INSIGHT

Endogenous vs. Exogenous Oxalates

Endogenous oxalate production is more significant than dietary oxalate for most people.
Focus on oxalate metabolism within the body, not just dietary intake.

INSIGHT

Dietary vs. Endogenous Oxalate Contribution

Dietary oxalate contributes 24% to urinary oxalate on a low-oxalate diet and up to 53% on a low-calcium, high-oxalate diet.
Endogenous production usually accounts for 60% or more of total oxalate.

INSIGHT

Genetic Disorders and Oxalate

Three rare genetic disorders, primary hyperoxaluria types 1-3, affect oxalate metabolism.
These disorders highlight the importance of specific enzymes in oxalate production.

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In this episode we discuss:

How much oxalate your body produces and how it compares to the amount you consume in your diet
Whether you need to be concerned about vitamin C, hydroxyproline, and glycine converting to oxalates
How you can reduce the amount of oxalates your body produces
Which nutrients decrease oxalate production
How metabolic dysfunction affects oxalate production

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes:
https://www.jayfeldmanwellness.com/ep-129-the-forgotten-source-of-oxalates-your-bodys-own-production/

Timestamps:

0:00 – intro

1:12 – overview of endogenous vs. exogenous oxalates

5:46 – how much oxalate comes from endogenous production vs. diet

9:14 – when endogenous oxalate production matters more than dietary oxalate

15:03 – rare genetic disorders that cause excessive oxalate production: primary hyperoxaluria

22:36 – the pathways in the liver that lead to oxalate production

32:41 – other biochemical pathways involved in endogenous oxalate production

41:19 – deranged metabolic function as a primary driver of glyoxal production and lipid peroxidation

45:14 – the extent to which glycine and vitamin C contribute to endogenous oxalate formation

48:00 – how much does hydroxyproline contribute to oxalate production?

52:06 – the primary precursor to oxalate that’s often ignored (glyoxal)

55:08 – how oxidative stress drives oxalate production and how antioxidants help

1:01:20 – what causes the high oxalate levels seen in type 2 diabetes, obesity, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD)?

1:11:16 – the protective effects of glycine in states of excess oxalate production

1:15:54 – elevated stress hormones and gluconeogenesis increase oxalate production

1:22:43 – nutrient deficiencies that contribute to oxalate issues (vitamin B1, vitamin B6, and zinc)