The Evolving Wellness Podcast with Sarah Kleiner Wellness The Real Reason Hormone Replacement Works For Some + Not Others | Kashif Khan
Jun 25, 2025
Kashif Khan, an expert in genetics and personalized health, dives into the complexities of hormone replacement therapy. He shares why treatments can vary dramatically in effectiveness among individuals, particularly during perimenopause. The conversation highlights surprising environmental factors, like air fresheners, that can disrupt hormone balance. Kashif emphasizes the importance of understanding one's genetic makeup to tailor health approaches and offers insights into managing hormone-related challenges. Overall, this discussion inspires a more personalized view of wellness.
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Genetics Drive HRT Success
- Hormone replacement therapy (HRT) effects vary because each body’s genetic blueprint alters how hormones are metabolized and detoxified.
- Understanding your unique gene variants can help personalize HRT and avoid adverse reactions.
Genes Shape Relationship Dynamics
- Kashif shares his and his husband's genetic differences influencing emotional responses and behaviors.
- Understanding genetic wiring helps explain relationship dynamics and emotional reactions.
Support Estrogen Detox Pathways
- To personalize hormone treatment, monitor estrogen metabolism pathways and detoxification capacity to avoid inflammatory metabolites.
- Support detox pathways with supplements like DIM, I3C, and calcium D-glucarate to reduce hormone-related inflammation.