Dive into the mysterious Sweating Sickness that struck England in the 1400s and 1500s, leaving a trail of confusion and terror. Explore the possible causes of this deadly illness, from viral and bacterial origins to unique characteristics and historical context. Delve into the enigma of the Sweating Sickness and its disappearance, with theories ranging from influenza to Hantavirus Pulmonary Syndrome. Uncover the secrets of this historical epidemic and its relevance for preventing future outbreaks.
01:25:25
AI Summary
AI Chapters
Episode notes
auto_awesome
Podcast summary created with Snipd AI
Quick takeaways
The mysterious Sweating Sickness in England struck five times in the 1400s and 1500s, causing terror and confusion.
Various proposed pathogens like Hantavirus and relapsing fever do not fully align with Sweating Sickness symptoms and rapid progress.
Hantaviruses from rodents, moles, and shrews and Borrelia species can cause severe diseases with distinct symptoms and fatality rates.
Deep dives
Origins of Sweating Sickness and Its Terrifying Impact
Sweating Sickness emerged in 1485 in England as a rapid and deadly disease with symptoms of high fever, intense sweating, unquenchable thirst, body aches, delirium, and a rapid progression towards death. The quick onset and spread of the illness through rural areas left a lasting impression due to the unpredictable and fatal nature of the sickness.
Epidemics Unraveled: Patterns and Mysterious Disappearances
Five major epidemics of Sweating Sickness occurred between 1485 and 1551, each characterized by a swift onset in summer and disappearance within a few months. London and neighboring areas were the primary locations affected, with death tolls peaking rapidly. The disease briefly transgressed to continental Europe, fueling speculations about its origins and transmission patterns.
Potential Disease Explanations and Investigations
Various proposed disease origins, including ergot poisoning, Hantavirus, anthrax, and relapsing fever, each fail to fully align with the symptoms and rapid progression of Sweating Sickness. Though similarities exist, further research is needed to pinpoint the exact pathogen responsible for this historical medical mystery, shedding light on the unique and deadly nature of the disease.
Hantavirus and its Deadly Nature
Hantaviruses, RNA viruses commonly found in rodents, moles, and shrews, can cause severe diseases like Hantavirus pulmonary syndrome with high fatality rates. Sinombre virus, the most deadly Hantavirus, results in a fatality rate of 40-50%. Other Hantaviruses like Solvirus, Hantan virus, and Dobravavirus lead to hemorrhagic fever with renal syndrome, presenting symptoms like fever, muscle aches, headache, and abdominal pain.
Relapsing Fever and its Variability
Relapsing fever, caused by Borrelia species, includes louse-borne and tick-borne forms with differing epidemiological characteristics. While tick-borne relapsing fever is transmitted through tick bites, louse-borne relapsing fever arises from louse hemolymph contact. Symptoms of relapsing fever involve sudden onset high fever, joint pain, muscle aches, nausea, vomiting, and distinct rash presentations, with varying incubation periods and durations of illness.
Here’s a pop quiz for all of you: what disease makes you sweat profusely, run a slight fever, develop body aches and a pounding head and then makes you drop dead within hours of symptom onset? If you answered “I have no idea”, you passed! Because we haven’t a clue either. In this episode, we attempt to tease apart the mysterious sweating sickness, which struck only five times in the 1400s and 1500s in England, leaving in its wake terror, confusion, and a trail of bodies. Although the sweating sickness has not been seen since (or has it?), scientists and scholars continue to investigate this mysterious illness and propose various pathogens as the likely causative agent. Tune in to hear us go through the most popular explanations to see if we can form our own consensus on ‘the sweat’.