Mitolife Radio

Kidney Failure: It is Damaged Mitochondria

Nov 29, 2025
Dive into kidney health with an exploration of mitochondrial function, revealing how mitochondrial transcription factor A (TFAM) influences kidney performance. Learn about the interplay of vitamins and minerals like magnesium and the impact of exercise on boosting TFAM. Discover effective strategies to combat kidney failure, including systemic enzymes and lifestyle changes. Matt emphasizes the significance of nutrient balance and offers insights into antioxidants, melatonin, and unique supplements to enhance mitochondrial vitality.
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INSIGHT

Kidneys Are Mitochondrial Powerhouses

  • The kidneys are the second most mitochondria-dense organ after the heart and consume high oxygen.
  • High mitochondrial function is essential for kidney energy, filtration, and hormone activation.
ADVICE

Dissolve Fibrosis With Systemic Enzymes

  • Use systemic proteolytic enzymes (e.g., nattokinase, serrapeptase) on an empty stomach to reduce fibrosis.
  • Take them regularly to support fibrinolysis, circulation, and tissue repair.
INSIGHT

TFAM Loss Drives Kidney Failure

  • Loss of TFAM in kidney tubule cells causes mitochondrial DNA release, inflammation, fibrosis, and cell death.
  • TFAM is essential to package mtDNA and transcribe electron transport chain genes for energy production.
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