The Optispan Podcast with Matt Kaeberlein

Scientist Reacts: Why Megadosing Creatine Is A Waste Of Time

14 snips
Nov 22, 2025
Creatine is often dubbed a 'cognitive super-drug,' but the hype around mega-dosing is misleading. The hosts critically evaluate various claims from health influencers, debunking the idea that 20 grams a day is beneficial. They explore the actual effects on brain health, resistance training, and potential side effects. Insights on how to judge health claims and a simple, effective dosing protocol are shared. Ultimately, they recommend a modest daily intake of 5 grams while encouraging listeners to prioritize sleep and training.
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ADVICE

Five Grams Daily, Consistently

  • Take 5 grams of creatine daily and be consistent rather than mega-dosing intermittently.
  • Combine creatine with regular resistance training to get measurable muscle benefits.
INSIGHT

Dose Versus Consistency

  • There is little evidence that higher creatine doses outperform a standard maintenance dose.
  • Consistency over time matters more than short-term loading for most outcomes.
ANECDOTE

Hosts' Long-Term Use Stories

  • Nick Arapis began taking creatine in 2007 and has used 5–10 grams daily for almost 20 years.
  • Matt Kaeberlein started regular use around 2020 and typically takes five grams a day.
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