Neurology® Podcast Outcomes Following Acute Plasma Exchange for MOGAD
Jul 3, 2025
In this discussion, Dr. John Chen, a neurologist at the Mayo Clinic, dives into the promising outcomes of acute plasma exchange for MOGAD patients. He emphasizes the critical role of timing in treatment, revealing that immediate intervention can significantly enhance recovery. The conversation also explores the comparison of plasma exchange with emerging therapies, including neonatal FC receptor inhibitors. Chen addresses the delicate balance needed in managing steroid treatments and the ongoing quest for improved patient care through future clinical trials.
AI Snips
Chapters
Transcript
Episode notes
Early PLEX Boosts Recovery
- Plasma exchange (PLEX) leads to significant recovery in MOGAD, with 44% achieving full recovery and over 90% showing improvement.
- Early initiation of PLEX is the only modifiable factor that significantly improves outcomes.
When to Use Plasma Exchange
- Use plasma exchange mainly for severe MOGAD attacks or if corticosteroids fail to provide full recovery.
- Timing varies but median initiation is about 13 days; earlier treatment tends to correlate with better outcomes.
Safe Concurrent Steroids and PLEX
- Combining corticosteroids with plasma exchange is safe and they work synergistically.
- Unlike monoclonal antibodies, steroids are not washed out by concurrent plasma exchange.