The Human Upgrade: Biohacking for Longevity & Performance

How Urolithin A Helps Create Super T-Cells & Boosts Immunity – Dr. Anurag Singh : 999

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Nov 22, 2022

Dr. Anurag Singh, an immunologist and Chief Medical Officer at Amazentis, dives into the fascinating role of urolithin A in boosting mitochondrial health and immune function. He explains how this compound helps rejuvenate our cells by cleaning up metabolic waste and enhancing the immune system's response to aging and cancer. With insights on the connection between inflammation and immunological strength, he reveals how urolithin A can empower T cells, offering a fresh perspective on maintaining health and vitality as we age.

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INSIGHT

Urolithin A Benefits

Urolithin A, a compound found in pomegranates, has anti-aging, athletic, and cognitive benefits.
Direct supplementation is more effective than eating pomegranates due to gut bacteria variability.

INSIGHT

Urolithin A and Aging

Aging weakens muscle and immune function, increasing infection and cancer risks.
Urolithin A may mitigate these effects by improving cellular health.

ANECDOTE

Overtraining Consequences

Dave Asprey overtrained in his 20s, hindering weight loss and potentially his immune system.
Overtraining can cause mitochondrial dysfunction and immune issues.

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Timeline Nutrition sponsored this podcast.

IN THIS EPISODE OF THE HUMAN UPGRADE™… immunologist Anurag Singh, M.D., Ph.D., MBA, Chief Medical Officer at Amazentis, joins the show to talk about urolithin A’s connection between inflammation, aging and your mitochondria.

Urolithin A activates mitophagy and renews your mitochondria. “It takes all the cellular garbage that has been accumulating over the aging process,” Dr. Singh explains. “It revs it up, so it recharges. And so now, you're cleaning your metabolic waste products much more efficiently and they become the building blocks. This is mitochondrial biogenesis, and that means newer, healthy mitochondria coming in.”

This new conversation takes an exciting turn into immunity and your immune system’s two lines of defense: innate and adaptive. You’ll learn:

how inflammation plus aging (AKA inflammaging) contributes to a weakened immune system and a growing incidence of cancer as you age;
how inflammaging and cancer are connected to mitochondrial dysfunction specifically during the aging process; and
how to approach your immune health differently with this new knowledge.

A new study recently published in Immunity looks at how immune cells fight cancer better with a focus on immune modulation, immune cell exhaustion and immune responses. “A lot of urolithin A is anti-inflammatory, but a lot of it is immune modulation," Dr. Singh says. "So, it takes a rewiring of the immune system and makes it more conducive to stopping harmful immune responses.”

Watch this episode on YouTube!

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: To learn more about the benefits of urolithin A, go to https://www.timelinenutrition.com and use code UPGRADE10 to get 10% off the plan of your choice.

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