New Books in Neuroscience

Kevin J. Tracey, "The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes" (Penguin, 2025)

Jul 12, 2025
Dr. Kevin J. Tracey, a neurosurgeon and researcher at the Feinstein Institute, delves into the fascinating world of the vagus nerve and its pivotal role in health. He uncovers how stimulating this nerve can reverse inflammation and treat chronic illnesses, transforming patients' lives. Hear inspiring stories of recovery from conditions like rheumatoid arthritis and depression. Dr. Tracey shares practical lifestyle strategies, such as meditation and exercise, to enhance vagus nerve function, opening doors to innovative therapies in neuroimmunology.
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INSIGHT

Vagus Nerve's Extensive Role

  • The vagus nerve is the longest nerve in the body, extending from the brainstem through the neck, chest, and abdomen.
  • It connects the brain to almost every organ, maintaining vital bodily functions and homeostasis.
ANECDOTE

Discovery of Vagus Nerve's Immune Role

  • Kevin Tracey's lab accidentally discovered the vagus nerve's role in controlling inflammation while testing an anti-inflammatory drug.
  • Cutting the vagus nerve blocked the anti-inflammatory effect, revealing a brain-immune system signal via the nerve.
INSIGHT

Neuro-Immune Circuit Explains Inflammation Control

  • Vagus nerve signals originate in the brainstem and travel to the spleen, modulating immune cells to reduce inflammation.
  • This neuro-immune circuit influences inflammation even at distant sites like joints in rheumatoid arthritis.
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