The Curious Clinicians 105 - Grapes of Pseudomonas's Wrath
Feb 20, 2025
Dive into the curious world of Pseudomonas aeruginosa, the gram-negative bacterium known for its grape-like aroma. Discover the historical roots of this intriguing organism and how its smell has impacted microbiology diagnostics. Learn about the timeless olfactory skills of microbiologists, who can identify bacteria by scent. Unravel the mystery of 2-aminoacetophenone (2AA), a compound linked to both cystic fibrosis and the off flavors in spoiled wine. It’s a fascinating blend of science, smell, and a dash of winemaking!
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Origin of Pseudomonas Curiosity
- Avi Cooper's interest in Pseudomonas' grape scent originated during his pre-med work in a burn unit.
- He observed the scent in burn patients' wounds and became curious about the connection.
Pseudomonas Discovery
- Pseudomonas aeruginosa was first isolated in 1882 by Carl Gissard from blue-green pus on soldiers' bandages.
- This discovery was at the forefront of microbiology, shortly after Robert Koch's groundbreaking work.
Identifying Bacteria by Smell
- Tony Brew shares an anecdote about Steve Brecker, a microbiologist, who could identify bacteria by smell.
- Brecker's experience demonstrates how scent can be a useful, though not definitive, diagnostic tool.