Real Time with Bill Maher Overtime – Episode #704: Andrew Huberman, Frank Bruni, Christopher Rufo
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Aug 26, 2025 
Join neuroscientist Andrew Huberman, known for his research at Stanford and as the host of the Huberman Lab podcast, alongside journalist Frank Bruni and activist Christopher Rufo. They dive into the societal implications of the weight-loss drug Ozempic and discuss changing beauty standards in media. The trio also debates the health risks of alcohol versus cannabis, examines the legacy of Richard Nixon in light of the Watergate scandal, and highlights the benefits of gut health linked to dietary choices like raw milk.
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Ozempic Reveals Energy-Balance Reality
- Ozempic clarified that obesity largely results from consuming more calories than are burned, reaffirming basic energy-balance principles.
- Huberman warns weight regained after stopping the drug unless people preserve muscle via resistance training.
Combine Drugs With Lifestyle And Strength Work
- Consider microdosing or using compounding pharmacies as lower-cost Ozempic strategies, paired with lifestyle changes.
- Always combine pharmaceutical approaches with resistance training, sleep, sunlight, and unprocessed foods to sustain results.
GLP‑1 Effects Extend Beyond Appetite
- GLP-1 drugs act beyond appetite and can reduce alcohol cravings and treat some addictions.
- Huberman notes these broader physiological effects may be beneficial and carry side effects like nausea.
