NEJM This Week NEJM This Week — October 2, 2025
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Oct 1, 2025 This week, the discussion highlights a groundbreaking trial comparing IV and oral rehydration methods for treating severe acute malnutrition in children. Listeners learn about a study linking imaging-related radiation to a slight increase in pediatric cancer risk. New research reveals a promising treatment for RSV in infants, significantly cutting hospitalization rates. The podcast also delves into the implications of corporate governance in healthcare and the impact of pharmaceutical tariffs on generic drug availability.
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IV Rehydration May Be Safe In Severe Malnutrition
- Intravenous rehydration produced similar short-term survival to oral rehydration in children with severe acute malnutrition and gastroenteritis.
- The trial challenges longstanding guidance against IV fluids and suggests IV options may be safe in these settings.
Pediatric Imaging Carries Small Cancer Risk
- Cumulative low-dose radiation from pediatric imaging associates with a small but measurable increase in hematologic cancer risk.
- The study estimated about 10% of pediatric hematologic cancers might be attributable to medical-imaging radiation exposure.
APOC3 Targeting Lowers Triglycerides Effectively
- Olizarsin, an APOC3-targeting antisense oligonucleotide, significantly reduced triglycerides at six months versus placebo.
- Serious adverse events were similar across groups, indicating promising efficacy with an acceptable short-term safety profile.