Do you really know? Why do some men get ill after they orgasm?
Nov 18, 2025
Explore the rare and intriguing condition known as postorgasmic illness syndrome (POIS), where some men face debilitating symptoms after orgasm. Dive into the various theories behind its causes, from autoimmune responses to hormonal imbalances. Hear real-life impacts on intimacy, with one man even opting out of sex altogether. Finally, learn about different treatments, including a promising case where a common antihistamine significantly alleviated symptoms. This thought-provoking discussion challenges conventional notions of sexual health.
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POIS Is A Recurrent, Debilitating Condition
- Post-orgasmic illness syndrome (POIS) causes physical and emotional symptoms after ejaculation, often within 30 minutes and lasting 2–7 days.
- Symptoms occur in over 90% of ejaculation events, making POIS a chronic, recurring condition that severely impacts sufferers' lives.
Causes Remain Unclear And Multifactorial
- Scientists don't know the single cause of POIS, and multiple mechanisms are proposed including autoimmune, hormonal, or neurochemical factors.
- The uncertainty explains why treatments have been inconsistent and often only partly effective.
Real Case: Man Quit Sex Due To POIS
- Some men stop having sex entirely because POIS devastates their wellbeing and relationships.
- The podcast cites a 27-year-old who quit sex after symptoms began at 18, illustrating real-life impact.