The HemOnc Pulse cover image

The HemOnc Pulse

‘The HemOnc Pulse’ Live: Unanswered Questions in T-Cell Lymphoma

May 30, 2024
Experts at 'The HemOnc Pulse' Live discuss uncertainties in T-cell lymphoma management including transplant timing, novel agents for relapsed/refractory cases, potential of JAK inhibitors, exploring different CAR T constructs, and benefits of sequencing for actionable mutations.
32:21

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Quick takeaways

  • The debate on transplants in T-cell lymphoma includes considerations for upfront hydrotherapy and stem cell rescue vs. waiting for relapse confirmation.
  • Emerging CAR T cell therapies and JAK inhibitors present potential advancements in treating specific T-cell lymphoma subtypes, necessitating further research collaborations.

Deep dives

Unanswered Questions in T Cell Lymphomas and Transplant Considerations

Debates around the role of transplants in T cell lymphomas remain unresolved, focusing on whether to proceed with hydrotherapy and stem cell rescue upfront or wait for relapse confirmation for fitter patients. The ongoing discussions emphasize the need for randomized studies to determine the efficacy of transplants in different settings, such as frontline remission. The controversy centers on selecting potentially favorable outcomes based on patient fitness and chemo-sensitivity.

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