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Psychopharmacology and Psychiatry Updates

Lithium, Lamotrigine, and Labor: Managing Bipolar Disorder in Expectant Mothers

Oct 3, 2024
Vivien Burt, M.D., a specialist in bipolar disorder, discusses the complexities of managing this condition during pregnancy. She emphasizes the critical balance between maternal mental health and fetal safety. The conversation covers the risks and benefits of medications like lithium and lamotrigine. Individualized treatment plans are highlighted as essential for effective care. The episode also explores recent research and guidelines for navigating these unique challenges, ensuring the well-being of both mother and child.
09:32

Episode guests

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Quick takeaways

  • Managing bipolar disorder in pregnant women involves evaluating the risks and benefits of medications while prioritizing both maternal mental health and fetal safety.
  • Lithium is often the preferred treatment for bipolar disorder in pregnancy due to its effectiveness, while Lamotrigine may be considered for those experiencing predominantly depressive episodes.

Deep dives

Guiding Principles for Managing Bipolar Disorder in Pregnancy

Treating bipolar disorder during pregnancy requires careful consideration of the patient's mental health stability. For individuals with mild illness and a history of stability off medication, a monitored approach to withholding mood stabilizers during the first trimester may be viable. However, for those with moderate to severe illness, continuing effective mood stabilizers and other psychiatric medications is essential to prevent relapse. Close monitoring is critical, as discontinuation of medication can increase the risk of decompensation during both pregnancy and the postpartum period.

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