Rena Malik, MD Podcast: Optimizing Health, Sex & Relationships with Science Backed Tips from Leading Experts

Testosterone Therapy 101: Risks, Benefits & Types of TRT ft. Dr. Mohit Khera

May 9, 2025
Dr. Mohit Khera, a leading urologist and expert in sexual health, joins the conversation to discuss the global decline in testosterone and its implications. He emphasizes that symptoms are more important than mere blood test numbers and explains the value of free testosterone. The discussion covers various testosterone replacement therapy options, their benefits, and risks to fertility. Dr. Khera also delves into innovative treatments for erectile dysfunction and the impact of lifestyle changes on hormone levels and overall health.
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INSIGHT

Free Testosterone Over Total T

  • Free testosterone level is a better indicator of symptoms than total testosterone.
  • Patients with low free testosterone but normal total testosterone are usually symptomatic.
ADVICE

Choose TRT by Four Cs

  • Consider injectables, orals, gels, or pellets for testosterone replacement therapy.
  • Choose based on cost, compliance, convenience, and concentration specific to each patient.
ADVICE

Protect Fertility on TRT

  • Never give exogenous testosterone to men trying to conceive as it acts as a natural contraceptive.
  • Use fertility-preserving agents like Clomid or HCG instead to boost natural testosterone production.
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