Founder's Journal How to Become Relentless as an Entrepreneur (Kian Sadeghi, Nucleus)
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May 28, 2024 
Kian Sadeghi, founder of Nucleus, shares his journey from dropping out of UPenn to building a genetic testing company. He discusses the importance of relentlessness, talent identification, personal tragedy inspiring genomics, and embracing fear and self-belief in entrepreneurship.
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Tragedy Sparks Interest
- Kian Sadeghi's cousin tragically died in her sleep, attributed to "bad genetics".
- This sparked his interest in genetics, leading him to a DIY gene-editing lab in Brooklyn.
Programming's Advantage
- Kian realized that programming's iterative nature made it faster for experimentation than biology.
- This led him to study computational biology, combining programming, statistics, and genetics.
Vision for Nucleus
- In a lecture on decreasing genome sequencing costs, Kian foresaw the need for an application layer for DNA.
- This inspired him to start Nucleus, envisioning a human genome on every smartphone.