In this episode of Longevity by Design, our host Dr. Gil Blander welcomes Dr. Aubrey de Grey, a biomedical gerontologist, to explore the frontiers of aging research and lifespan extension. Dr. de Grey shares his work identifying and addressing the seven major categories of aging-related diseases. He discusses how targeted damage repair offers a promising alternative to traditional methods to slow aging, providing a path to longer, healthier lives.

The conversation delves into the hallmarks of aging, their implications for medical research, and the challenges of translating results from animal models to human applications. Dr. de Grey emphasizes the importance of combining multiple interventions, such as senolytics, gene therapy, and stem cell treatments, to achieve significant gains in lifespan. He also shares insights from his work with the LEV Foundation and the Methuselah Foundation.

Listeners will gain a deeper understanding of the science behind rejuvenation and the potential for humanity to reach longevity escape velocity within the coming decades. Dr. de Grey underscores the critical role of continued research, innovation, and funding in accelerating progress toward defeating aging-related diseases.

Episode highlights:

Introduction: 00:00:00
The Seven Hallmarks of Aging: A Foundational Framework: 00:07:00
Challenges in Funding Longevity Research: 00:15:00
Lifestyle, Genetics, and the Limits of Current Longevity: 00:23:00
The Methuselah Foundation and Early Longevity Advocacy: 00:37:00
Top tip to improve healthspan: 00:52:00

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The Path to a 1,000-Year Lifespan with Dr. Aubrey de Grey