Hugues de Thé

Collège de France

Oncologie cellulaire et moléculaire

Année 2025-2026

Hematopoietic Stem Cell through the Ages: A Lifetime of Adaptation to Organismal Demands

Conférence - Emmanuelle Passegué : Principle of Hematopoietic Stem Cell Biology and Blood Production

Emmanuelle Passegué

Directrice de la Columbia Stem Cell Initiative et professeure émérite de génétique et de développement à l'université Columbia

Résumé

Unlike most adult organs, the blood system regenerates continuously to maintain homeostasis in a life-long process orchestrated by a complex collection of hematopoietic stem and progenitor cells. Self-renewing HSCs reside at the apex of this hierarchy and produce all blood lineages, including the erythroid lineage that forms red blood cells, the megakaryocytic lineage that gives rise to platelets, and the myeloid and lymphoid lineages that generate cells of the innate and adaptive immune systems. Most HSCs exist in a quiescent state, dividing occasionally to self-renew and produce various lineage-biased multipotent progenitors that form a transit amplifying compartment sustaining the daily output of the blood system. We will consider how emerging concepts in cell differentiation and lineage priming are developing our understanding of the hematopoietic hierarchy and its functional attributes.