The Feed 150- Building the future of personalized nutrition with Jonathan Wolf of ZOE
Jun 9, 2025
Jonathan Wolf, Co-founder and CEO of ZOE, discusses revolutionizing nutrition with personalized approaches based on the gut microbiome and large-scale studies. He shares how ZOE uses machine learning to tailor dietary advice and the importance of mindful eating for long-term success. Jonathan emphasizes the value of adding beneficial foods instead of restrictive dieting and reveals how real-time meal scoring and processed food transparency can transform our choices and the food industry.
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From Ad Tech To Personalized Nutrition
- Jonathan Wolf moved from ad-tech personalization at Criteo to founding Zoe after seeing nutrition and microbiome science at scale.
- A personal history of food intolerances and meeting Professor Tim Spector sparked the shift to apply AI to nutrition.
Microbiome Is The Food–Health Mediator
- The gut microbiome mediates much of how food affects long-term health via chemicals produced by microbes.
- Modern diets have far fewer fibers and polyphenols, reducing microbiome diversity and resilience.
Large-Scale Science Underpins Personalization
- Zoe runs the world's largest nutrition science study and uses that data to build personalized dietary advice.
- Their randomized controlled trial in Nature Medicine showed Zoe's approach outperformed standard care on multiple health metrics.