The New Probiotic Strain That Allows You To Eat Carbs Again, How GLP-1 Peptide Actually Works And Why It's Not Intended For Everyone

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Oct 14, 2023

Colleen Cutliffe, a microbiome expert and founder of Pendulum Therapeutics, delves into the fascinating world of gut health. She discusses the unique role of Akkermansia muciniphila in managing blood sugar levels and its link to GLP-1 peptides. Colleen shares insights about natural substances that can help regulate metabolism and highlights how individual microbiomes impact nutrient absorption. The conversation also touches on the gut's influence on mental health and the intricate relationship between diet and microbiome balance.

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INSIGHT

Gut Microbiome's Role in Metabolism

The gut microbiome plays a significant role in metabolism, explaining why individuals respond differently to the same foods.
This discovery has opened new avenues for understanding and managing metabolic health through microbiome interventions.

INSIGHT

GLP-1 Production

GLP-1, a molecule that stimulates insulin response and reduces cravings, is produced in the gut microbiome.
The microbiome metabolizes fiber into short-chain fatty acids, which then trigger GLP-1 production.

ADVICE

GLP-1 Drugs and Healthy Individuals

Avoid GLP-1 drugs like Ozempic if you don't have diabetes, as they constantly elevate GLP-1 levels, disrupting natural cycles.
This can lead to side effects and potential long-term issues with insulin regulation.

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You might've heard me say it before: "The gut is the second brain."

With over two decades of leadership in biotech, pharma, and academia, my guest on today's show, Colleen Cutliffe, is gut-deep :) in microbiome knowledge. Her path, spanning from the hallowed halls of Johns Hopkins University to groundbreaking initiatives at Pacific Biosciences and Elan Pharmaceuticals, showcases an unyielding curiosity about the mysteries of the human body. Now, as the driving force behind Pendulum Therapeutics, Colleen is charting new territories in the world of the microbiome.

Akkermansia muciniphila, one of Pendulum's products, is a unique oval-shaped bacterium that thrives in the human gastrointestinal tract. This anaerobic microbe predominantly resides at the junction between oxygen-rich and oxygen-depleted zones of the intestines. Found in about 90% of healthy individuals, it constitutes 1% to 3% of your fecal microbiota. However, its prevalence can decrease with age or certain diseases.

In today's chat, Colleen unravels the enigma of the gut-brain axis and its monumental influence on the microbiome's functionality. She sheds light on the role of natural agents like berberine, bitter melon extract, apple cider vinegar, and even pharmaceuticals like metformin in regulating blood sugar. With insights into the importance of Akkermansia muciniphila in GLP-1 production and the captivating genetic variations within the microbiome, this conversation promises a comprehensive look at gut health like never before.

Full show notes: https://bengreenfieldlife.com/pendulumpodcast

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