The Metabolic Link Warburg Effect in Sporadic Alzheimer's & Ketogenic Therapy for MS Patients | Journal Club | The Metabolic Link Ep. 21
In this episode, our co-hosts Victoria Field, Dominic D’Agostino, PhD, and Angela Poff, PhD, discuss two recent scientific studies that focus on the potential metabolic connections to neurodegenerative diseases.
Study 1: Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease
The study delves into the molecular changes causing a neuron's transition from healthy to degenerative, as seen in sporadic Alzheimer's, which is the most prevalent form of Alzheimer's disease and isn't directly inherited but arises from a mix of genetic and environmental factors. It proposes that metabolic changes in neurons due to altered gene expression might play a role in the disease's onset. Today's discussion touches upon the similarities between the findings in this study and the well-established Warburg Effect seen in cancer. This study may provide a clue to the molecular mechanisms behind Alzheimer’s disease and open the door for exploration of potential treatments.
Study 2: Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability, and potential clinical benefits
This study measured the impact of a dietitian-guided ketogenic diet on MS patients on several markers including body composition, mood, mental health, and physical stamina.
Our co-hosts discuss these findings as well as the secondary benefits of ketogenic therapies due to reduced MS symptoms, and the unique challenges of dietary vs pharmaceutical trials, such as ensuring accuracy, participant compliance and how to measure the intervention’s effectiveness.
If you'd like to read the papers referenced above, please find them here: Study 1 & Study 2
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