Big Idea: Struggling with High Blood Pressure and Inflammation? You Might Need to Improve Your Nitric Oxide—Here's How

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Jun 30, 2025

Dr. Nathan Bryan, a leading expert in nitric oxide research with over 20 years in molecular medicine, shares critical insights on the importance of nitric oxide for cardiovascular health. He explains how low levels can lead to heart disease and other serious conditions. Listeners will discover lifestyle changes to boost nitric oxide naturally, like diet, exercise, and proper breathing. The conversation also delves into the dangers of certain medications, like proton pump inhibitors, and their effects on heart health. A must-listen for anyone interested in bettering their overall health!

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INSIGHT

Nitric Oxide Deficiency Impacts Health

Nitric oxide deficiency is the earliest event in most chronic diseases.
Symptoms include high blood pressure, sexual dysfunction, metabolic decline, and cognitive issues.

INSIGHT

Endothelium and Heart Health

Cardiovascular disease is directly linked to endothelial dysfunction from nitric oxide loss.
Healthy endothelium produces nitric oxide to regulate blood flow and prevent inflammation.

INSIGHT

Nitric Oxide as Healing Signal

Nitric oxide is a gaseous signaling molecule regulating oxygen delivery and healing.
It activates stem cells for tissue repair, key to anti-aging and regeneration.

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This episode is brought to you by Cozy Earth and Maui Nui.

Each year, nearly 700,000 lives are lost to cardiovascular disease—and half of those individuals had no warning signs before their event. One major contributing factor? Low levels of nitric oxide, a vital molecule that supports healthy blood flow and keeps blood vessels flexible. The good news is that lifestyle changes—like diet, exercise, and proper supplementation—can naturally boost nitric oxide levels, helping to reduce your risk and support long-term heart health.

Today on The Dhru Purohit Show, we’re revisiting one of our most talked-about moments with Dr. Nathan Bryan, all about why nitric oxide is the most underrated molecule for both short- and long-term health. Dhru and Dr. Bryan explore the connection between low nitric oxide levels and major conditions like heart disease, high blood pressure, Alzheimer’s, sexual dysfunction, and metabolic decline. They also dive into the biggest blockers of nitric oxide production, the top foods and lifestyle choices to naturally boost it, signs of deficiency, and so much more.

Dr. Nathan Bryan is a leading expert in molecular medicine and nitric oxide research, with over 20 years of groundbreaking work and dozens of global patents. He’s the founder of Nitric Oxide Innovations, a company developing nitric oxide-based therapies to improve health worldwide.

In this episode, Dhru and Dr. Bryan dive into:

What happens in the body when we don’t produce enough nitric oxide (1:17)
The link between nitric oxide and heart health (3:30)
How nitric oxide is produced in the body (11:22)
Habits that boost nitric oxide production (15:07)
How mouthwash inhibits nitric oxide production (17:05)
Nasal breathing and nitric oxide production (29:18)
The impact of proton pump inhibitors on creating nitric oxide (32:23)
Foods to avoid and transitioning to an anti-inflammatory diet (40:16)
High blood pressure and its link to nitric oxide (42:17)
Final thoughts (44:58)

Also mentioned:

Full episode with Dr. Nathan Bryan

This episode is brought to you by Cozy Earth and Maui Nui.

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