Dr. Trish Leigh Podcast

Episode #195: Neuroscientist Explains the Hidden Cost of Dopamine Abstinence

Nov 9, 2025
Discover why going cold turkey on dopamine can backfire and leave you feeling worse. Explore the concept of the dopamine illusion, where novelty-driven highs lead to deep crashes. Learn how overstimulation shows up on brain maps and manifests in issues like erectile dysfunction. Dr. Trish shares her journey from overstimulation to rewiring and offers practical steps for restoration. Emphasizing regulation over restriction, she reveals how to reset pleasure pathways in your life for long-lasting well-being.
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INSIGHT

Dopamine Teaches, It Doesn't Reward Forever

  • Dopamine is a teacher, not a trophy, and signals what matters to your brain.
  • Excess external novelty floods and misguides dopamine into compulsive chasing and crash cycles.
INSIGHT

Chasing Spikes Creates Compulsion

  • Constant novelty produces spikes that drop below baseline, creating emptiness and a need to chase more hits.
  • This chase becomes compulsion: not pleasure but pressure and craving to escape discomfort.
ADVICE

Rewire Instead Of Just Abstain

  • Don't expect calm from sheer abstinence; the circuitry remains dysregulated and can cause relapse or flatness.
  • Focus on rewiring the reward system rather than only removing the stimulus.
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