Huberman Lab

Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

668 snips
Jul 8, 2024
Guest
Matthew Hill
Dr. Matthew Hill, a professor at the University of Calgary and a cannabis biology expert, dives deep into the impact of cannabis on health. He discusses how THC and CBD affect the brain differently, including their links to appetite and stress regulation. The conversation tackles the risks of high-potency cannabis, its potential role in mental health issues, and whether it can be addictive. Listeners will gain insights into various consumption methods and the complex relationship between cannabis and cognitive functions.
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INSIGHT

Cannabis, CB1 Receptors, and Endocannabinoids

  • THC primarily acts on CB1 receptors, widely expressed in the brain.
  • The body produces endocannabinoids like anandamide and 2-AG, which also bind to CB1 receptors to maintain homeostasis.
INSIGHT

Endocannabinoid Types and Functions

  • Anandamide has a high affinity for CB1 receptors but low efficacy, acting as a tonic regulator.
  • 2-AG has lower affinity but high efficacy, acting as a phasic regulator during high activity.
INSIGHT

The Munchies: How Cannabis Affects Appetite

  • Cannabinoids influence appetite through multiple mechanisms, including hypothalamic circuits, reward circuitry, and enhanced sweet taste perception.
  • The "munchies" effect may involve overriding satiety signals and reward devaluation.
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