#71 - Aging, inactivity, atrophy and exercise with Professor Sue Bodine

Dr Glenn McConell chats with Professor Sue Bodine from the Oklahoma Medical Research
Foundation, Oklahoma, USA. She is an expert on muscle, in particular muscle atrophy with inactivity/aging. We chatted about how with age muscle size is reduced and this is associated with a reduction in muscle fiber size and also a loss of fast muscle fibers. Resistance training (and perhaps intense endurance exercise) can attenuate the rate of muscle atrophy. We discussed how much muscle atrophy is due to age per se and how much is due to inactivity. Anabolic resistance, protein synthesis, the importance of strength for balance etc. A very interesting chat.
0:00. Introduction + how Sue got into exercise research
5:25. What determines muscle strength
7:20. What age do we start losing muscle mass and strength?
8:40. Muscle atrophy and loss of fast muscle fibers
13:10. Can exercise training reduce the loss of fast fibers with age?
17:50. How muscle of muscle atrophy with age in inactivity?
19:20. Anabolic resistance with age
20:40. A role of hormones in muscle atrophy with age?
22:30. Protein synthesis and turnover in muscle with aging
26:46. How much exercise is needed to attenuate muscle atrophy?
30:30. Aging vs inactivity vs immobilizing vs bed rest etc
33:30. Importance of exercise after bed rest/immobilization
37:27. Upper body atrophy in runners/cyclist etc
39:55. Intense endurance exercise and slow muscle fiber size
43:00. Need to actually work out not just turn up
44:42. Exercise prescription with aging
47:05. Balance with age/inactivity
48:45. Diet and muscle atrophy
50:00. Need a stimulus (ex training) not eating more protein
54:52. Disease processes and muscle atrophy
58:10. Mechanisms playing a role in muscle atrophy/hypertrophy
1:08:53. Don’t need to break down muscle to build muscle
1:10:40. Determining muscle quality/specific tension
13:02. Are slow fibers really weaker than fast fibers?
1:17:22. Takeaway messages
1:18:53. Can very old people still get stronger/hypertrophy?
1:19:50. Do females really hypertrophy less?
1:22:00. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
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Not medical advice