Research on immunometabolism highlights the role of the MCT11 lactate transporter in T cell exhaustion. A study presented by Ronel Peralotta showed that exhausted T cells have a greater capacity to uptake lactic acid compared to regular T cells, which is mediated by MCT11. The findings suggest that inhibiting this transporter can improve outcomes in mouse tumor models, potentially breaking the cycle of T cell exhaustion caused by chronic lactate exposure. This underscores the intricate relationship between metabolic adaptations in T cells and their functional capacities in tumor environments.
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, the annual meeting of the American Association of Immunologists in Chicago, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of five special episodes from the meeting, where Brenda and Jason talk about sessions including the dysfunction of exhaustive T cells enforced by MCT11-mediated lactate metabolism and extrafollicular differentiated B cells, presented by former podcast guest