Huberman Lab

Dr. Karl Deisseroth: Understanding & Healing the Mind

Jun 28, 2021

02:00:23

Creator website

Episode guests

Karl Deisseroth

AI Summary

Highlights

AI Chapters

Episode notes

Podcast summary created with Snipd AI

Quick takeaways

Channel opsins derived from algae have the potential to revolutionize psychiatric treatments by allowing for precise control of neuron activity using light.

Advancements in optogenetics, including the use of channel opsins, offer an opportunity to increase understanding and develop more precise and effective treatments for psychiatric disorders by targeting specific circuits and cells in the brain.

Optogenetic interventions, particularly with channel opsins, hold promise for more targeted and personalized treatments, although further research is needed to deepen our understanding and refine the methodology for delivering light stimulation.

Psychodelic medicine, such as psychedelics like LSD and psilocybin, provides unique opportunities for the treatment of psychiatric conditions by altering brain circuitry and enhancing emotional connectedness, but rigorous research and careful administration are necessary.

Deep dives

Channel opsins and their potential in treating psychiatric illnesses

Channel opsins, proteins derived from algae, have the potential to revolutionize the treatment of psychiatric illnesses and nervous system disorders. These proteins can be introduced into the nervous systems of animals and humans, allowing for precise control of neuron activity in the brain and body using light. Unlike traditional drug treatments, channel opsins offer a more targeted approach, avoiding side effects and increasing treatment efficacy. They have shown promise in the treatment of depression, schizophrenia, epilepsy, and other conditions. Recent advancements have even enabled the restoration of vision in a blind patient using channel opsins. While further research is needed, this transformative technology has the potential to greatly impact the fields of psychiatry and mental health in the future.

Understanding the Complexity of Animal Brain Studies

01:00

Quantitative Tests for Psychiatric Diseases

00:53

Balancing Work, Family, and Communication

01:11

The Biggest Challenge for Psychiatry?

02:23

Introduction

2min

Pro Actions by Karl Disroth

4min

Inside Tracker

2min

Neurology vs Psychiatry - What's the Difference?

2min

Is It Easier to Diagnose a Depressed Patient?

2min

The Biggest Challenge for Psychiatry?

2min

Psychiatry

3min

Do You Think That Dopomin Is Linked to Depression?

3min

Psychiatry - Do You Know When You're in Trouble?

2min

10.

Is There Any Treatment for Psychiatric Disease?

2min

11.

Is Electro Convulsive Therapy Effective for Depression?

2min

12.

What Is the Bento Box of the Perfect Cure?

2min

13.

What Is the Key Principle of Social Interaction?

3min

14.

How Do You Generate Channel Ossens?

2min

15.

Plant Behavior - The Secret of Plant Behavior

3min

16.

The Evolution of Optogenetics

3min

17.

The Broader Significance of Optogenetics Clinically

2min

18.

Did You Decide to Become a Scientist to Cure Fine Cures for Mental Disease?

4min

19.

How to Control Algy Proteins Using Light

4min

20.

Is the Vagus a Reason to Treat Depression?

3min

21.

Optical Stimulation

2min

22.

Aa Gean Delivery Mechanisms

2min

23.

How to Make a Light Sensitive Opsin?

2min

24.

What's Happening in Real Time?

2min

25.

Eye Contact - What Are You Looking For?

3min

26.

Eye Contact in Psychiatry

2min

27.

The Eyes Are a Portal to Over All Arousal State

4min

28.

Psychiatrists Take the Drugs They Prescribe

2min

29.

What if We Had Better Specificity?

3min

30.

Is There a Pill Base Treatment for a Psychiatric Disease?

2min

31.

What Are Your Thoughts About a Brain Machine in Her Face?

3min

32.

What Is True a D H D?

4min

33.

Do You Have a Dh D?

3min

34.

How Do You Organize the Day?

3min

35.

Are You Using Visual Tools to Harness Your Mind?

3min

36.

Are Your Kids Writers?

3min

37.

How to Transform a Brain Into a Cellular Structure

2min

38.

Is the Human Brain Adapted to Animals?

3min

39.

Do You Have a Seizure Disorder?

2min

40.

The Power of Optogenics

2min

41.

Psychodelic Medicine

3min

42.

The Risks of Psychodelics

3min

43.

The Psychological Effects of the Psychedelics

3min

44.

Mdma, Ecstasy

2min

45.

Are You an Optimist?

3min

46.

Doctor Diseroth's New Book Projections - A Story of Human Emotions

3min

Dr. Karl Deisseroth, MD, PhD, is a clinical psychiatrist and scientist who directs a bioengineering research laboratory at Stanford University School of Medicine. His work aims to understand and develop treatments for disorders of the mind such as depression, attention deficit disorders (ADHD & ADD), autism, schizophrenia, anxiety, eating disorders, borderline personality and obsessive-compulsive disorder. We discuss his experience treating his patients and his laboratory’s mission to find and develop cures for mental disease and tools for probing how the brain works.

Read the full show notes for this episode at hubermanlab.com.

Thank you to our sponsors

AG1: https://athleticgreens.com/huberman

LMNT: https://drinklmnt.com/hubermanlab

Waking Up: https://wakingup.com/huberman

Momentous: https://livemomentous.com/huberman

Timestamps

00:00:00 Introduction

00:03:47 Sponsors: AG1, LMNT & Waking Up

00:07:41 Using Language to Understand the Mind

00:12:19 Blood Tests For Mental Disease

00:13:38 The Largest Challenges Facing Treatment of Mental Health

00:20:21 Predicting Depression & Suicide

00:22:47 Drugs That Work for Brain Illness

00:27:01 What Would A Cure For the Broken Mind Look Like?

00:32:23 Channelopsins: Tools For Understanding & Treating the Mind

00:39:10 Curing Blindness with Channelopsins

00:41:58 Why Karl Became a Scientist

00:47:10 Vagus Nerve In Depression

00:54:12 Challenges To Overcome for Treating Mental Illness with Channelopsins

00:58:34 Using the Dialogue with Patients to Guide Treatment

01:00:52 How Our Eyes Reveal Our Mental Health

01:06:04 Controlling Structures Deep In the Brain

01:08:23 The Most Effective Drugs Often Have the Most Side Effects

01:09:50 Do Psychiatrists Take the Drugs They Prescribe

01:14:15 Moving From Experimental Tools To Novel Treatments

01:16:00 Brain-Machine Interfaces & Neuralink

01:19:30 ADHD & Dr. Deisseroth’s Approach To Focusing His Mind

01:26:36 How Dr. Deisseroth Balances A Career In Medicine, Science & Family

01:35:41 New Ways of Exploring Brains: CLARITY

01:38:49 What Is Special About the Human Brain?

01:46:03 Psychedelics

01:54:12 MDMA

01:57:15 Dr. Deisseroth’s New Book “Projections: A Story of Emotions”

01:59:42 Connecting with Dr. Deisseroth on Twitter

Disclaimer & Disclosures

Get the Snipd
podcast app

Unlock the knowledge in podcasts with the podcast player of the future.

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode

Save any
moment

Hear something you like? Tap your headphones to save it with AI-generated key takeaways

Share
& Export

Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode

Huberman Lab

Dr. Karl Deisseroth: Understanding & Healing the Mind

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

Deep dives

Channel opsins and their potential in treating psychiatric illnesses

The need for a better understanding of psychiatric disorders

Current limitations in psychiatric treatments

The potential of optogenetics for targeted brain stimulation

The Power of Psychodelic Medicine

The Potential of MDMA in Trauma Treatment

Exploring Dissociation and Optogenetics

Optimism for the Future of Psychiatry

Understanding the Complexity of Animal Brain Studies

Quantitative Tests for Psychiatric Diseases

Balancing Work, Family, and Communication

The Biggest Challenge for Psychiatry?

Thank you to our sponsors

Timestamps

Get the Snipd
podcast app

AI-powered
podcast player

Discover
highlights

Save any
moment

Share
& Export

AI-powered
podcast player

Discover
highlights

Huberman Lab

Dr. Karl Deisseroth: Understanding & Healing the Mind

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

Deep dives

Channel opsins and their potential in treating psychiatric illnesses

The need for a better understanding of psychiatric disorders

Current limitations in psychiatric treatments

The potential of optogenetics for targeted brain stimulation

The Power of Psychodelic Medicine

The Potential of MDMA in Trauma Treatment

Exploring Dissociation and Optogenetics

Optimism for the Future of Psychiatry

Understanding the Complexity of Animal Brain Studies

Quantitative Tests for Psychiatric Diseases

Balancing Work, Family, and Communication

The Biggest Challenge for Psychiatry?

Thank you to our sponsors

Timestamps

Get the Snipdpodcast app

AI-poweredpodcast player

Discoverhighlights

Save anymoment

Share& Export

AI-poweredpodcast player

Discoverhighlights

Get the Snipd
podcast app

AI-powered
podcast player

Discover
highlights

Save any
moment

Share
& Export

AI-powered
podcast player

Discover
highlights