The podcast features experts in CLL therapy discussing topics like the impact of MRD, comparative analysis of BTK inhibitors, challenges in defining cure, selecting BTKIs in frontline therapy, and optimizing treatment strategies for young CLL patients. They debate on therapy duration, patient outcomes, and future approaches in treating high-risk CLL patients.
Consider patient selection criteria for CLL therapy options and the role of measurable residual disease (MRD) in treatment decisions.
Evaluate the selection of BTK inhibitors in CLL treatment based on factors like comorbidities, treatment responses, and treatment tolerability.
Deep dives
Unanswered Questions in CLL Therapy
The podcast episode delves into the unanswered questions surrounding chronic lymphocytic leukemia (CLL) therapy. Panelists discuss critical points such as patient selection criteria for different treatment options, the role of measurable residual disease (MRD) in treatment decisions, and the sequencing of therapies in CLL management. Specific areas of focus include time-limited therapy, the relevance of MRD, and the impact of therapy selection on long-term outcomes.
Treatment Selection and Efficacy
The discussion revolves around the selection of BTK inhibitors in CLL treatment. Panelists explore the considerations between acalabrutinib and ibrutinib, highlighting factors such as comorbidities, treatment responses, and the importance of treatment tolerability. The debate emphasizes the need for high-risk randomized studies to compare continuous therapy versus venetoclax-based approaches, offering insights into efficacy and patient outcomes.
Outlier Scenarios and CAR-T Therapy in CLL
An outlier scenario involving a younger patient with multiple lines of therapy and exceptional chemo sensitivity to specific treatments is examined. The panel discusses the potential role of CAR-T therapy in CLL for refractory cases and contrasts it with allogeneic transplantation, considering factors like treatment toxicity and patient age. The conversation highlights the complex treatment decisions in outlier cases and the evolving landscape of cellular therapies in CLL management.
Future Directions and Unmet Needs
The podcast concludes with insights into future research directions and areas of unmet needs in CLL management. Topics include immune reconstitution, immune effects of therapy, and the impact of treatment modalities on patient immune systems. The panelists stress the importance of immune-directed therapies, post-lymphoid cell treatment, and the challenges posed by Richter's transformation in CLL patients.
Part one of this episode explores questions in measurable residual disease (MRD) and chronic lymphocytic leukemia (CLL) with Mazyar Shadman, MD, MPH, of Fred Hutchinson Cancer Center; Meghan Thompson, MD, of Memorial Sloan Kettering Cancer Center; and Alan Skarbnik, MD, of Novant Health.
“The HemOnc Pulse” was live for in Chicago, Illinois, on May 3-4 and featured host Chadi Nabhan, MD, MBA, FACP, moderating panels of academic and clinical experts who delved into unanswered questions in various hematologic malignancies.
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