This Podcast for the Neurology Journal begins and closes with Dr. John H. Noseworthy, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Elliot Dimberg interview Dr. Frans Brugman about his paper on adult-onset upper motor neuron syndromes. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about ateplase-associated hemi-orolingual angioedema. The podcast concludes with Dr. Richard Bedlack interviewing Dr. Paul Gordon on the topic of primary lateral sclerosis for the Lesson of the Week segment. The participants had nothing to disclose except for Dr. Bedlack. He has a research grant from UCB Pharma related to a study on primary lateral sclerosis.