Environmental factors impacting intestinal inflammation were highlighted through research involving a zebrafish model of colitis. A notable study identified various toxins that either worsened or improved colitis symptoms, leading to the discovery of 13 harmful and 4 beneficial agents. One specific herbicide, pro-pizamide, was shown to exacerbate inflammation by inhibiting the aryl hydrocarbon receptor (AHR) signaling pathway, which is crucial for regulating responses to gut microbiota. This innovative approach utilizing zebrafish and machine learning suggests significant potential for environmental assessments in gut health research.
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, the annual meeting of the American Association of Immunologists in Chicago, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of five special episodes from the meeting. Brenda and Jason discuss highlights from sessions including microbial and environmental influences on the gut and recent breakthroughs in emerging therapeutic strategies for chronic inflammatory and fibrotic diseases.