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Tricuspid Valve Endocarditis Prevalence
- Tricuspid valve endocarditis is more common in IV drug users.
- Studies show 68% of endocarditis cases in IV drug users involve the tricuspid valve, compared to 5% mitral and 7% aortic.
Endocarditis Pathogenesis
- Endocarditis requires valvular endothelial injury, thrombus formation, and bacterial infection.
- Vegetations rarely form on intact endothelium, highlighting the importance of injury.
Endothelial Injury
- High pressures and velocities across heart valves likely cause endothelial injury.
- Robert's venturi tube experiment demonstrated that bacteria gather in low-pressure sinks.