Longevity Optimization with Kayla Barnes-Lentz Exploring Metabolic Health with Nick Norwitz, MD, PhD
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Jul 31, 2025 
Nick Norwitz, MD, PhD, a metabolism researcher and educator, dives deep into metabolic health's hidden layers, discussing GLP-1s' effects on mood and cognition beyond weight loss. He highlights the surprising impact of pets on cognitive decline and childhood allergies, while exploring the complexities of the gut microbiome. Discover his thoughts on the limits of evidence-based medicine and the power of personal experimentation. Plus, insights on nutrition, brain health, and why understanding your body's signals is crucial!
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Recovery Through Diet
- Nick Norwitz described severe ulcerative colitis that destroyed his athletic and academic performance in his 20s.
- A ketogenic diet resolved his symptoms and restored his health, prompting his metabolic-health focus.
Why Metabolic Therapies Are Overlooked
- Nick argues conventional evidence-based medicine underinvests in metabolic interventions due to incentive structures.
- This leaves low-hanging dietary and lifestyle therapies unexplored despite potential high impact.
Run N-of-1 Experiments
- Treat your life as an experiment: form a hypothesis, test lifestyle changes, and iterate based on data.
- Use outcomes and biomarkers to guide choices rather than ideological diets.