BI 148 Gaute Einevoll: Brain Simulations

Sep 25, 2022

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The Difference Between Beautiful and Ugly Models

Is the Human Brain Project Going to End?

Is There Pushback From the Neuroscience Community?

A Review of the Scientific Case for Brain Simulations

The Degeneracy in Neuroscience

Isfot Reglan, You're a Patrand Subscriber to Podcast

How Do You Extract Principles From Complex Model Simulations?

A and Hen Be Able to Extract Some Principles From Comparing the Different Granularity Models

Predicting Local Field Potentials of a Neural Network

The History of Spikes in the Brain of an Animal

The Local Field Potential Is a Spectral Measurement of the Neurons

Do Lf P Signals Predict Spikes?

Measurement Physics

The Usefulness Form for Modelling Signals

Computition Neuro Science Community Is Not So Big, Right?

Synapses and Synaptic Plasticity

How Do You Decide How Many Components?

The Importance of Local Field Potentials in Paramidal Neurons

Aspects of Forward Modeling of Electrical A, Electrical Signals

01:02:11 • 4min

Scaling Up Neural Field Models

01:06:08 • 5min

Is Local Field Potential a Way to Predict an LFP Signal?

01:10:56 • 2min

Neural Oscillatory Dynamics

01:12:32 • 4min

How to Measure a Neural Network?

01:16:26 • 2min

I Think It's a Fantastic Opportunity for for Newer Scinceone

01:18:21 • 3min

The Connection Between Deep Learning and Nervo Science

01:21:35 • 3min

Do You Think Simulation Based Deep Learning Could Help Artificial Intelligence?

01:24:44 • 4min

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Gaute Einevoll is a professor at the University of Oslo and Norwegian University of Life Sciences. Use develops detailed models of brain networks to use as simulations, so neuroscientists can test their various theories and hypotheses about how networks implement various functions. Thus, the models are tools. The goal is to create models that are multi-level, to test questions at various levels of biological detail; and multi-modal, to predict that handful of signals neuroscientists measure from real brains (something Gaute calls "measurement physics"). We also discuss Gaute's thoughts on Carina Curto's "beautiful vs ugly models", and his reaction to Noah Hutton's In Silico documentary about the Blue Brain and Human Brain projects (Gaute has been funded by the Human Brain Project since its inception).

Gaute's website.
Twitter: @GauteEinevoll.
Related papers:
LFPy: a Python module for calculation of extracellular potentials from multicompartment neuron models.
Gaute's Sense and Science podcast.

0:00 - Intro 3:25 - Beautiful and messy models 6:34 - In Silico 9:47 - Goals of human brain project 15:50 - Brain simulation approach 21:35 - Degeneracy in parameters 26:24 - Abstract principles from simulations 32:58 - Models as tools 35:34 - Predicting brain signals 41:45 - LFPs closer to average 53:57 - Plasticity in simulations 56:53 - How detailed should we model neurons? 59:09 - Lessons from predicting signals 1:06:07 - Scaling up 1:10:54 - Simulation as a tool 1:12:35 - Oscillations 1:16:24 - Manifolds and simulations 1:20:22 - Modeling cortex like Hodgkin and Huxley