#233 The Science of Hunger: GLP-1, Appetite Control & Natural Weight Management With Sarah Kennedy

Why does hunger feel so loud — and why does willpower so often fail?

In this illuminating episode, Sarah Kennedy, founder and CEO of Calocurb, unpacks the biology of hunger, the gut-brain axis, and the powerful role of GLP-1 in appetite regulation. Drawing on over 15 years and $30 million of New Zealand government-backed science, Sarah explains why hunger is driven by our most primitive brain systems — and how understanding this biology can finally bring peace with food.

We explore how bitter taste receptors in the gut stimulate appetite-suppressing hormones, why dieting can actually increase hunger over time, and how natural GLP-1 activation differs fundamentally from pharmaceutical injections like Ozempic.

We explore:

• The evolutionary biology of hunger and food noise
• How GLP-1, CCK and PYY regulate appetite
• Why calorie restriction backfires long-term
• Natural vs synthetic GLP-1 pathways
• How appetite regulation supports metabolic health, insulin sensitivity & longevity

This is a science-grounded, compassionate conversation that reframes hunger — not as a personal failure, but as biology you can finally work with.

This episode was brought to you by:

• Calocurb

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