Overview of Von Willebrand's disease and focus on Type 2

In this episode, the hosts continue their discussion on Von Willebrand's disease, specifically focusing on Type 2. They highlight the difference between Type 2A, which involves a loss of high molecular weight multimers, and Type 2B, which is characterized by a gain of function mutation resulting in enhanced platelet aggregation. They also discuss Type 2M, which involves a loss of platelet binding, and Type 2N, characterized by a decreased factor 8 binding. The hosts emphasize the importance of accurate diagnosis through advanced testing, including multimer analysis and Ristocetin-induced platelet aggregation tests. They also mention the role of genetic testing in identifying specific subtypes. The discussion concludes with insights into perioperative management for patients with Von Willebrand's disease, including the use of DDAVP for Type 1 patients and exogenous factor replacement for Type 2B, 2M, 2N, and Type 3 patients.