Nature Podcast

Menopause and women’s health: why science needs to catch up

May 3, 2023
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INSIGHT

Menopause Is A Brain Transition

  • Menopause affects the brain via disrupted hormonal cycles during perimenopause rather than only being a 'reproductive' issue.
  • Brain metabolism and temperature regulation can be thrown into disarray before estrogen levels settle post-menopause.
INSIGHT

Why Menopause Research Lags

  • Studying menopause is hard because animal models rarely mimic human menopause and human experiences vary widely.
  • This variability complicates epidemiology and slows research progress.
ANECDOTE

A Researcher's Path To Hot-Flash Drugs

  • Naomi Rance studied post-mortem brains and found neurons that looked bigger after menopause.
  • That finding led to targeting neurokinin B and a new class of drugs for hot flashes.
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