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Menopause Is A Brain Transition
- Menopause affects the brain via disrupted hormonal cycles during perimenopause rather than only being a 'reproductive' issue.
- Brain metabolism and temperature regulation can be thrown into disarray before estrogen levels settle post-menopause.
Why Menopause Research Lags
- Studying menopause is hard because animal models rarely mimic human menopause and human experiences vary widely.
- This variability complicates epidemiology and slows research progress.
A Researcher's Path To Hot-Flash Drugs
- Naomi Rance studied post-mortem brains and found neurons that looked bigger after menopause.
- That finding led to targeting neurokinin B and a new class of drugs for hot flashes.