The Poultry Podcast Show
Dr. Karel Antoni Schat: Subclinical Immunosuppression | Ep. 100
Jul 30, 2024
Dr. Karel Antoni Schat, Professor Emeritus of Avian Virology and Immunology at Cornell University, sheds light on critical poultry health challenges. He explains subclinical immunosuppression, its impact on diseases like Marek's and chicken infectious anemia, and stresses the significance of early detection and management strategies. Dr. Schat discusses the complexities of viral adaptations and the potential of innovative tools like CRISPR in combating avian diseases. His insights underscore the importance of optimal conditions for poultry health.
37:25
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Quick takeaways
- Subclinical immunosuppression in poultry, often exacerbated by environmental factors, compromises vaccine efficacy and increases disease susceptibility.
- Optimal management practices and advanced vaccine strategies are essential for preventing immunosuppression and enhancing overall poultry health.
Deep dives
Understanding Subclinical Immunosuppression
Subclinical immunosuppression refers to a temporary or permanent dysfunction of the immune system due to various insults, ultimately leading to increased susceptibility to diseases. This condition often diminishes the efficacy of vaccines, as seen in vaccines for Newcastle disease where inadequate responses can occur due to damaged T-helper cells caused by viruses like chicken anemia virus. Major infectious agents causing this condition include Marek's disease and infectious bursal disease, which can impair the immune system without presenting overt clinical signs. Identifying and understanding these underlying issues is crucial for maintaining poultry health and ensuring effective vaccination practices.
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