The Neuro Experience

What Are the 3 Key Blood Tests for Alzheimer's Detection? | A Woman’s Guide to Alzheimer’s Disease | Part 2

Mar 26, 2025
Alzheimer's disease is a slow, silent process that can begin decades before symptoms appear. The discussion dispels the myth that it’s purely genetic, highlighting the influence of the APOE4 gene coupled with lifestyle factors. Women, particularly post-menopause, face unique vulnerabilities. Listeners will learn about three innovative blood tests that can identify early signs of Alzheimer's. The conversation also covers essential prevention strategies, including managing blood sugar, hormones, and inflammation to protect cognitive health.
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INSIGHT

Alzheimer's and Genetics

  • Alzheimer's disease is largely influenced by lifestyle and metabolic health, not solely genetics.
  • Only about 1-3% of cases are caused by deterministic genes, according to Louisa Nicola.
INSIGHT

APOE4 Gene and Risk

  • The APOE4 gene increases Alzheimer's risk, but it's not a guarantee of developing the disease.
  • Having one copy increases risk 2-3x, while two copies increase it 10-12x.
INSIGHT

APOE4 and Brain Health

  • APOE4 affects brain energy, increasing insulin resistance and inflammation.
  • Women with APOE4 are at higher risk due to estrogen's protective role, especially after menopause.
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