Change Your Brain Every Day Holly Madison Opens Up About Her Autism Diagnosis, Battling Depression & Reveals Her Brain Scan Results
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Jun 29, 2026 
Holly Madison, television personality and two-time NYT bestselling author, discusses receiving an adult autism diagnosis and her long struggle with depression. She talks about her motivations for getting a brain scan and what the results revealed. Conversations cover memory, ADD-like patterns, trauma from the Playboy Mansion era, and practical steps for improving brain health and daily resilience.
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Adult Autism Diagnosis Clarified Social Struggles
- Holly Madison discovered her adult autism diagnosis after seven assessment appointments and it clarified longstanding social difficulties.
- She said the diagnosis helped her stop assuming she “just doesn't like being around people” and gave a target to tackle social challenges.
Negativity Is A Trainable Brain Pattern
- Daniel Amen interprets chronic negativity as a brain pattern that drives depression and damages relationships over time.
- He highlights that training the brain toward positivity can markedly improve mood and interpersonal function.
Increase Wellbutrin To Match Brain Needs
- Daniel Amen recommends increasing bupropion (Wellbutrin) dose for Holly because it treats both depression and adult ADD symptoms.
- He compares medication dosing to eyeglass prescription: use the dose that fits your brain, not the smallest one.
