Mitolife Radio Why I Megadose Melatonin Every Night
Oct 31, 2025
The podcast dives into the fascinating benefits of megadosing melatonin, debunking common myths surrounding its use. Contrary to popular belief, melatonin has significant anti-tumor, anti-viral, and anti-anxiety properties. It’s primarily produced in mitochondria, not just the pineal gland, and surprisingly, supplementation can enhance your body's own production. Insights on melatonin's roles in EMF protection, periodontal health, and even mental health challenges make for intriguing listening. Plus, practical dosing tips and sourcing advice wrap up the discussion!
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Melatonin Is Largely Mitochondrial
- Most melatonin (>95%) is produced in mitochondria across cells, not primarily by the pineal gland.
- Nighttime pineal secretion comprises less than 5% of total melatonin production.
Supplementing Can Boost Your Own Melatonin
- Exogenous melatonin can increase endogenous production by reactivating pyruvate dehydrogenase and supplying acetyl-CoA.
- This counters the common belief that supplements suppress natural melatonin synthesis.
Melatonin's Antioxidant And Mitochondrial Roles
- Melatonin is a powerful antioxidant that scavenges hydroxyl radicals and protects lipids, proteins, and DNA.
- It also enhances mitochondrial ATP production by improving mitochondrial interfacial water and ATP synthase function.