Brain Ponderings podcast with Mark Mattson Thomas Sudhof: Molecular Codes for Synapse Formation and Specificity
In this episode I talk with Stanford Professor and Nobel laureate Thomas Sudhof about his work that has advanced an understanding of the molecular machinery for neurotransmitter release, a remarkable process that is compex, occurs rapidly (milliseconds) and is highly localized (1 micrometer or less). We then talk about the even more difficult problem of the molecular mechanisms that control the formation, maintenance and plasticity of synapses. The current model of the molecular code for synapse specificity and adaptability involves a uniform array of presynaptic proteins and a highly variable array of postsynaptic proteins.
LINKS
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866025/pdf/nihms-531222.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226307/pdf/nihms-1509679.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689449/pdf/nihms914499.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694349/pdf/nihms917636.pdf