The Optispan Podcast with Matt Kaeberlein The Dangerous Truth About The Peptide Craze (I Tried It)
Dec 6, 2025
Matt shares his thrilling experiences from longevity conferences in Geneva, Chicago, and Mauritius, contrasting alternative and evidence-based approaches. He critiques the overhyped peptide craze, stressing the lack of efficacy and potential risks. A cultural divide emerges as he discusses the clash between data-driven medicine and anecdotal practices. With insights on aging myths and facts, he emphasizes the importance of validated tools in healthspan care. The episode wraps up with practical health tips like sauna routines and reflections on the future of longevity research.
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Reset Jet Lag With Early Workouts
- If you suffer jet lag, try waking early and using hotel gym workouts to reset your rhythm.
- Matt Kaeberlein found 3:30 AM workouts reduced daytime tiredness and improved travel recovery.
Longevity Conferences Vary Widely In Rigor
- Many longevity conferences mix solid science with alternative-medicine talks lacking rigorous data.
- Matt emphasizes balance: exciting biology exists, but clinicians need detailed evidence on effects and side effects.
Skip Unvalidated Aging-Clock Tests
- Avoid spending money on unvalidated direct-to-consumer aging clocks.
- Matt advises reallocating that cash toward a gym membership or healthier food instead.