The Curious Clinicians 101 - Automatic ABO
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Dec 11, 2024 Discover why we automatically form antibodies to ABO blood type antigens that aren't our own. Explore the fascinating history of blood transfusions, from early experiments to understanding compatibility. Dive into the complexities of antibody production and the impact of gut microbes. Uncover how infants develop anti-ABO antibodies and the implications for transfusions and heart transplants. This exploration of blood types reveals intriguing evolutionary insights and highlights the importance of immunology in medicine.
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ABO Incompatibility and Antibodies
- ABO incompatibility causes acute hemolytic transfusion reactions.
- We don't usually make antibodies to things without prior exposure.
Early Transfusion Attempts
- Modern transfusion medicine began in 1628 with William Harvey's discovery of blood circulation.
- Early transfusions between animals were successful, but human-animal transfusions failed.
Discovery of Blood Groups
- Karl Landsteiner theorized three blood groups (A, B, C) and later added AB.
- Ludwig Hecht-Dohen suggested cross-matching blood in 1907, and group C became the universal donor (O).